Master thesis deals with multi-material structural design that is based on reference architectural model. We performed process and product analysis that is relevant for multi-material structural design and proposed and demonstrated its use for three construction materials (concrete, steel and wood) In the frames of process analysis we used IDEFØ methodology to describe AS-IS structural design. A detailed description of process models of existing design procedures for building permit and production documentation is presented. We also proposed TO-BE multi-material structural design process model. In the process analysis main project stakeholders and their roles were taken into account. To achieve desired re-engineering into multi-material structural design the whole building design and BIM were identified as driving forces. The multi-material design is first illustrated on simple case study. In the frames of building product analysis construction technologies and their potential advantages and disadvantages in the case of three construction materials is given. In the concluding part the result of process and product modelling of multi-material structural design is demonstrated on a larger building. Modelling is executed using BIM tools (Tekla Structures, LigniKon and ArchiCAD) that are used for architectural and structural design. Demonstrated multi-material structural design procedure is based on the architectural reference model, which was created in ArchiCAD. The workflow takes the advanced of inter-operability between ArchiCAD and Tekla Structures using the IFC standard. In addition, an overview of applicability of several BIM tools for multi-material modelling is given. We also assess important issues for the inter-operability between BIM tools and provide suggestions for the improvements and further development of multi-material design.