Monitoring displacements and deformations of anthropogenic spatial structures and objects represents one of the most intricate areas in geodetic surveying. Besides the measurement technologies that have been traditionally used for such tasks, terrestrial laser scanning represents another possibility employing the surface-wise deformation inspection of the objects’ surfaces. The main aim of the thesis is to try to provide answers whether terrestrial laser scanning can be used for monitoring displacements and deformations in a long-term perspective and how this could be achieved for any arbitrary surface. Furthermore, the hypothesis will be challenged with the statement that the deformation inspection can be performed in the millimeter domain with this remote sensing measurement technology. In order to solve the problem of a stable reference system and to assure the high quality of possible position changes of point clouds, scanning is integrated with two complementary surveying techniques, i.e., high quality static GNSS positioning and precise classical terrestrial surveying. The methodology of such high precision monitoring approach is proposed in the thesis and was tested in two case study outdoor experiments. Besides these two outdoor experiments, also indoor tests were designed to evaluate the quality of the surveying equipment (laser scanning targets) as well as the response of the scanner to the surface material.