This thesis presents the load-bearing structure of the multi-residential masonry building in Nova Gorica. There are 28 sheltered rental housings. Floor constructions and the roof of the building are both made as solid reinforced concrete plate. The vertical load-bearing structure of the building consists of a brick masonry walls, but in the stair core area the walls are made of reinforced concrete. The first part of the thesis presents analysis and design of the typical reinforced concrete plate in accordance with the Eurocode standards. An idealized mathematical model of the plate was made in the program SAP2000. The analysis of the plate is concluded by the upper and lower reinforcement plans, which are annexed to this thesis. In the second part of the thesis is checked a load-bearing capacity of a brick masonry on the ground floor while the vertical and horizontal seismic load operate on them. In the vertical load is checked the wall, where the average compressive stresses, in the horizontal cross section of the wall, are higher. It is established that the load-bearing capacity of the wall is appropriate. In the operation of the horizontal seismic load is estimated the total shear resistance of the masonry without the contribution of the reinforced concrete wall in the stair core. It is established that without the cooperation RC walls, brick masonry is not able to assume the estimated horizontal seismic load.